Vaccines are in the news every day as some countries struggle to improve vaccination rates and others struggle to access vaccines. A social science approach is needed to further explore what actions can be taken to optimize vaccine acceptance during a disease outbreak, with immediate lessons for the COVID-19 pandemic. Social science can highlight histories of oppression, political-economic contexts that exacerbate inequality, and how communities experience injustice with implications for how individuals view, trust, and take up vaccines. In this Epicast, we explore social science perspectives on vaccine deployment through the lens of Project AViD: Anthropological Exploration of Facilitators and Barriers to Vaccine Deployment and Administration During Disease Outbreaks.